BindingDB PrimarySearch

Found 20 Enz. Inhib. hit(s) with all data for entry = 50000337

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

IC50: 0.0280nMAssay Description:Inhibition of human recombinant PDE4B expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 0.0880nMAssay Description:Inhibition of human recombinant PDE4B expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 660nMAssay Description:Inhibition of human recombinant PDE7A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 810nMAssay Description:Inhibition of human recombinant PDE10A2 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 3.46E+3nMAssay Description:Inhibition of human recombinant PDE7A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 3.56E+3nMAssay Description:Inhibition of human recombinant PDE8A1 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 4.03E+3nMAssay Description:Inhibition of human recombinant PDE10A2 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 4.61E+3nMAssay Description:Inhibition of human recombinant PDE5A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 6.21E+3nMAssay Description:Inhibition of human recombinant PDE3A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: 7.40E+3nMAssay Description:Inhibition of human recombinant PDE1A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 1.39E+4nMAssay Description:Inhibition of human recombinant PDE5A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 1.70E+4nMAssay Description:Inhibition of human recombinant PDE8A1 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: 2.56E+4nMAssay Description:Inhibition of human recombinant PDE1A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE2A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE9A2 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246909(CHEMBL4075951)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE11A4 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE2A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE9A2 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE3A expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL

BDBM50246908(CHEMBL4093768)

IC50: >3.00E+4nMAssay Description:Inhibition of human recombinant PDE11A4 expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Filter my 20 hits

Targets 10▿
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 2
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 2
- cGMP-specific 3',5'-cyclic phosphodiesterase 2
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 2
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2
- cGMP-dependent 3',5'-cyclic phosphodiesterase 2
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 2
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 2
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 2
Publications 1▿
- J Med Chem 60: 10026-10046 (2017) 20
Institutions 1▿
- Chiesi Farmaceutici 20
Affinity: 0.028 to 3.0E+4 nM▿
- IC50 20
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0