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Found 43 Enz. Inhib. hit(s) with all data for entry = 50007499
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  1nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  14nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041176(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  42nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041176(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  430nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041179(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  700nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041179(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  900nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064044((S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':...)
Affinity DataIC50:  970nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041179(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064048(7-Benzyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064048(7-Benzyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064044((S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064047(7-(3,4,5-Trimethoxy-benzyl)-5,6,7,8-tetrahydro-pyr...)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  1.31E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064048(7-Benzyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064048(7-Benzyl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041176(2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl...)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064042(7-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064046(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064046(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)
Affinity DataIC50: >2.04E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064042(7-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  2.06E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064044((S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':...)
Affinity DataIC50:  2.15E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064042(7-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064046(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)
Affinity DataIC50: >2.28E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064046(7-(3,5-Dimethoxy-benzyl)-5,6,7,8-tetrahydro-pyrido...)
Affinity DataIC50:  2.28E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064042(7-(3,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  2.41E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064043(7-(2,6-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  3.17E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064047(7-(3,4,5-Trimethoxy-benzyl)-5,6,7,8-tetrahydro-pyr...)
Affinity DataIC50: >3.50E+4nMAssay Description:Inhibition of T. gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064047(7-(3,4,5-Trimethoxy-benzyl)-5,6,7,8-tetrahydro-pyr...)
Affinity DataIC50: >3.50E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064047(7-(3,4,5-Trimethoxy-benzyl)-5,6,7,8-tetrahydro-pyr...)
Affinity DataIC50: >3.50E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064043(7-(2,6-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  4.05E+4nMAssay Description:Inhibition of P. carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  5.09E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064043(7-(2,6-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: >8.12E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in M. avium.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064043(7-(2,6-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50:  8.12E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064044((S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':...)
Affinity DataIC50:  8.58E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair