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Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM327883
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
<500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM327883
Synonyms:
(6-(3- (benzyloxy)phenyl) pyridin-3-yl)(4-(4- fluorobenzyl)piperazin- 1-yl)methanone | US10377742, Compound 22 | US9663496, Compound 22
Type:
Small organic molecule
Emp. Form.:
C30H28FN3O2
Mol. Mass.:
481.5606
SMILES:
Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1
Structure:
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