Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase Mer
Ligand
BDBM336362
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<10±n/a nM
Citation
 Wang, X; Liu, J; Yang, C; Zhang, W; Frye, S; Kireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent  US9744172 Publication Date 8/29/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM336362
Synonyms:
US9744172, Compound UNC978A
Type:
Small organic molecule
Emp. Form.:
C22H30N6O3S
Mol. Mass.:
458.577
SMILES:
CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NS(C)(=O)=O)cc1 |r,wU:15.15,(12.18,-2.39,;10.85,-1.62,;9.52,-2.39,;8.18,-1.62,;6.85,-2.39,;5.52,-1.62,;5.52,-.08,;4.18,.69,;2.85,-.08,;1.38,.39,;.48,-.85,;1.38,-2.1,;.91,-3.57,;-.6,-3.89,;-1.07,-5.35,;-.04,-6.49,;-.52,-7.96,;1.46,-6.17,;1.94,-4.71,;2.85,-1.62,;4.18,-2.39,;.91,1.86,;-.6,2.18,;-1.07,3.64,;-.04,4.78,;-.52,6.25,;-2.03,6.57,;-2.35,5.06,;-3.53,6.89,;-1.71,8.08,;1.46,4.46,;1.94,3,)|
Structure:
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