Reaction Details
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3-phosphoinositide-dependent protein kinase 1 [51-360]
Ligand
BDBM365948
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<500±n/a nM
Citation
Lind, KE; Cao, K; Lin, EY; Nguyen, TB; Tangonan, BT; Erlanson, DA; Guckian, K; Simmons, RL; Lee, W; Sun, L; Hansen, S; Pathan, N; Zhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent US9873693 Publication Date 1/23/2018 More Info.:
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-360]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35373.34
Organism:
Homo sapiens (Human)
Description:
(aa 51-360)
Residue:
310
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
Inhibitor
Name:
BDBM365948
Synonyms:
US9873693, Compound 1
Type:
Small organic molecule
Emp. Form.:
C26H24F2N4O2
Mol. Mass.:
462.4912
SMILES:
Fc1ccc(Cn2cccc(C(=O)N[C@H]3CC[C@H](CC3)c3c[nH]c4ncccc34)c2=O)cc1F |r,wU:14.13,17.20,(9.6,6.01,;8.27,5.24,;6.93,6.01,;5.6,5.24,;5.6,3.7,;4.26,2.93,;4.26,1.39,;5.6,.62,;5.6,-.92,;4.26,-1.69,;2.93,-.92,;1.6,-1.69,;1.6,-3.23,;.26,-.92,;-1.07,-1.69,;-1.07,-3.23,;-2.4,-4,;-3.74,-3.23,;-3.74,-1.69,;-2.4,-.92,;-5.07,-4,;-5.07,-5.54,;-6.54,-6.01,;-7.44,-4.77,;-8.97,-4.61,;-9.6,-3.2,;-8.69,-1.95,;-7.16,-2.11,;-6.54,-3.52,;2.93,.62,;1.6,1.39,;6.93,2.93,;8.27,3.7,;9.6,2.93,)|
Structure:
