Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM25771
Substrate
BDBM25747
Meas. Tech.
3H-CGP 12177 Whole Cell Binding Assay
Kd
1862±n/a nM
Citation
 Baker, JG The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 144:317-22 (2005) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM25771
Synonyms:
1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-2-methylol-phenol | 4-(1-hydroxy-2-{[6-(4-phenylbutoxy)hexyl]amino}ethyl)-2-(hydroxymethyl)phenol | Aeromax | Salmeterol | Serevent | salmeterol xinafoate
Type:
Small organic molecule
Emp. Form.:
C25H37NO4
Mol. Mass.:
415.5656
SMILES:
OCc1cc(ccc1O)C(O)CNCCCCCCOCCCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM25747
Synonyms:
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride | CGP 12177 | CGP-12177 | CGP12177 | [3H]CGP 12177
Type:
radiolabeled ligand
Emp. Form.:
C14H21N3O3
Mol. Mass.:
279.3348
SMILES:
CC(C)(C)NCC(O)COc1cccc2[nH]c(=O)[nH]c12
Structure:
Search PDB for entries with ligand similarity: