Reaction Details Report a problem with these data
Target
Coagulation factor XI
Ligand
BDBM32693
Substrate
Boc-Glu-Ala-Arg-AMC
Meas. Tech.
Factor XIa Dose Response Confirmation from Single Well Screen
pH
7.4±n/a
Temperature
296.15±n/a K
IC50
>50000±0 nM
Citation
 PubChem, PC Factor XIa Dose Response Confirmation from Single Well Screen PubChem Bioassay (2008)[AID] 
Target
Name:
Coagulation factor XI
Synonyms:
Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent
Type:
Enzyme
Mol. Mass.:
70130.58
Organism:
Homo sapiens (Human)
Description:
P03951
Residue:
625
Sequence:
MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
  
Inhibitor
Name:
BDBM32693
Synonyms:
(3-chloranyl-4-oxidanylidene-chromen-7-yl) pyridine-3-carboxylate | (3-chloro-4-oxochromen-7-yl) pyridine-3-carboxylate | 3-pyridinecarboxylic acid (3-chloro-4-oxo-1-benzopyran-7-yl) ester | MLS000523505 | Nicotinic acid 3-chloro-4-oxo-4H-chromen-7-yl ester | SMR000122578 | cid_734291 | nicotinic acid (3-chloro-4-keto-chromen-7-yl) ester
Type:
Small organic molecule
Emp. Form.:
C15H8ClNO4
Mol. Mass.:
301.681
SMILES:
Clc1coc2cc(OC(=O)c3cccnc3)ccc2c1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Boc-Glu-Ala-Arg-AMC
Synonyms:
n/a
Type:
fluorescent substrate peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA