Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM33160
Substrate
FITC-conjugated-Bim BH3 Peptide
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
13820±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM33160
Synonyms:
1-benzyl-3-chloro-4-(2-hydroxy-5-methyl-anilino)-3-pyrroline-2,5-quinone | 1-benzyl-3-chloro-4-(2-hydroxy-5-methylanilino)pyrrole-2,5-dione | 1-benzyl-3-chloro-4-[(2-hydroxy-5-methylphenyl)amino]-1H-pyrrole-2,5-dione | 3-chloranyl-4-[(5-methyl-2-oxidanyl-phenyl)amino]-1-(phenylmethyl)pyrrole-2,5-dione | 3-chloro-4-(2-hydroxy-5-methylanilino)-1-(phenylmethyl)pyrrole-2,5-dione | MLS000626713 | SMR000299098 | cid_731393
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O3
Mol. Mass.:
342.776
SMILES:
Cc1ccc(O)c(NC2=C(Cl)C(=O)N(Cc3ccccc3)C2=O)c1 |c:8|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-conjugated-Bim BH3 Peptide
Synonyms:
FITC-Ahx-DMRPEIWIAQELRRIGDEFNAYYAR-OH
Type:
FITC-labeled Peptide
Mol. Mass.:
3112.46
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
DMRPEIWIAQELRRIGDEFNAYYAR