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Target
Bcl-2-related protein A1
Ligand
BDBM34173
Substrate
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Meas. Tech.
HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
pH
7±n/a
Temperature
296.15±n/a K
IC50
>100000±0 nM
Citation
 PubChem, PC HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM34173
Synonyms:
2-(3-chlorophenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-pyrimidin-2-yl-2H-pyrrol-5-one | 2-(3-chlorophenyl)-3-(furan-2-ylcarbonyl)-4-oxidanyl-1-pyrimidin-2-yl-2H-pyrrol-5-one | 2-(3-chlorophenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(2-pyrimidinyl)-2H-pyrrol-5-one | 5-(3-chlorophenyl)-4-(2-furoyl)-3-hydroxy-1-(2-pyrimidyl)-3-pyrrolin-2-one | MLS000037295 | SMR000036116 | cid_660196
Type:
Small organic molecule
Emp. Form.:
C19H12ClN3O4
Mol. Mass.:
381.769
SMILES:
Clc1cccc(c1)C1C(C(=O)c2ccco2)C(=O)C(=O)N1c1ncccn1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
FITC-Ahx-EDIIRNIARHLAQVGDSMDR
Synonyms:
FITC-Bid peptide
Type:
fluorescein-labeled peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
n/a
Residue:
3
Sequence:
NA