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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM36931
Substrate
n/a
Meas. Tech.
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Parental Cell Line Counter Screen 60K MLSMR
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Parental Cell Line Counter Screen 60K MLSMR PubChem Bioassay (2007)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM36931
Synonyms:
6-amino-1'-(4-chlorobenzyl)-2'-keto-3-methyl-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indoline]-5-carbonitrile | 6-amino-1'-[(4-chlorophenyl)methyl]-3-methyl-2'-oxo-5-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]carbonitrile | 6-amino-1'-[(4-chlorophenyl)methyl]-3-methyl-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile | 6-azanyl-1'-[(4-chlorophenyl)methyl]-3-methyl-2'-oxidanylidene-spiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-5-carbonitrile | MLS000082271 | SMR000044710 | cid_663934
Type:
Small organic molecule
Emp. Form.:
C22H16ClN5O2
Mol. Mass.:
417.848
SMILES:
Cc1[nH]nc2OC(=N)C(C#N)C3(C(=O)N(Cc4ccc(Cl)cc4)c4ccccc34)c12
Structure:
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