Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM37853
Substrate
n/a
Meas. Tech.
Cathepsin B Inhibitor Series SAR Study
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B Inhibitor Series SAR Study PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM37853
Synonyms:
PC-0094931 | PCMD-CC-MCM-15 | [5-amino-1-(4-methoxyphenyl)sulfonylpyrazol-3-yl] acetate | [5-azanyl-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ethanoate | acetic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester | acetic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ester | cid_11834383
Type:
Small organic molecule
Emp. Form.:
C12H13N3O5S
Mol. Mass.:
311.314
SMILES:
COc1ccc(cc1)S(=O)(=O)n1nc(OC(C)=O)cc1N
Structure:
Search PDB for entries with ligand similarity: