Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM37857
Substrate
n/a
Meas. Tech.
Cathepsin B Inhibitor Series SAR Study
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B Inhibitor Series SAR Study PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM37857
Synonyms:
4-pyridinecarboxylic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-3-pyrazolyl] ester | PC-0094936 | PCMD-CC-MCM-19 | [5-amino-1-(4-methoxyphenyl)sulfonylpyrazol-3-yl] pyridine-4-carboxylate | [5-azanyl-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] pyridine-4-carboxylate | cid_11834386 | isonicotinic acid [5-amino-1-(4-methoxyphenyl)sulfonyl-pyrazol-3-yl] ester
Type:
Small organic molecule
Emp. Form.:
C16H14N4O5S
Mol. Mass.:
374.371
SMILES:
COc1ccc(cc1)S(=O)(=O)n1nc(OC(=O)c2ccncc2)cc1N
Structure:
Search PDB for entries with ligand similarity: