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Target
Dual specificity protein phosphatase 6
Ligand
BDBM35415
Substrate
n/a
Meas. Tech.
In vitro MKP-3 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing
IC50
>50000±n/a nM
Citation
 PubChem, PC In vitro MKP-3 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing PubChem Bioassay (2007)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM35415
Synonyms:
1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-[2-(3-fluorophenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-1-propanone | 1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-[2-(3-fluorophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propan-1-one | 1-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-3-[2-(3-fluorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]propan-1-one | 8-{3-[2-(3-fluorophenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl]propanoyl}-1,4-dioxa-8-azaspiro[4.5]decane | MLS000089608 | SMR000027956 | cid_3245990
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O3
Mol. Mass.:
438.4946
SMILES:
Cc1nc2cc(nn2c(C)c1CCC(=O)N1CCC2(CC1)OCCO2)-c1cccc(F)c1
Structure:
Search PDB for entries with ligand similarity: