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Target
Bcl-2-related protein A1
Ligand
BDBM39169
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1
IC50
11500±1010 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1 PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
A1 | A1-A | B-cell leukemia/lymphoma 2 related protein A1a | B2LA1_MOUSE | Bcl2a1 | Bcl2a1a | Bfl-1 | Bfl1 | Hemopoietic-specific early response protein | Protein BFL-1
Type:
Apoptosis regulator protein
Mol. Mass.:
19909.74
Organism:
Mus musculus (Mouse)
Description:
gi_11024684
Residue:
172
Sequence:
MAESELMHIHSLAEHYLQYVLQVPAFESAPSQACRVLQRVAFSVQKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKKLPQEQIALDVCAYKQVSSFVAEFIMNNTGEWIRQNGGWEDGFIKKFEPKSGWLTFLQMTGQIWEMLFLLK
  
Inhibitor
Name:
BDBM39169
Synonyms:
3-chloranyl-4-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrole-2,5-dione | 3-chloro-4-[4-(2-hydroxyethyl)-1-piperazinyl]-1-(3-methylphenyl)pyrrole-2,5-dione | 3-chloro-4-[4-(2-hydroxyethyl)piperazin-1-yl]-1-(3-methylphenyl)pyrrole-2,5-dione | 3-chloro-4-[4-(2-hydroxyethyl)piperazino]-1-(m-tolyl)-3-pyrroline-2,5-quinone | MLS-0111706.0001 | cid_16654736
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O3
Mol. Mass.:
349.812
SMILES:
Cc1cccc(c1)N1C(=O)C(Cl)=C(N2CCN(CCO)CC2)C1=O |t:12|
Structure:
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