Reaction Details Report a problem with these data
Target
Estrogen receptor
Ligand
BDBM40499
Substrate
n/a
Meas. Tech.
Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation
EC50
12796.55±n/a nM
Citation
 PubChem, PC Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation PubChem Bioassay (2007)[AID] 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM40499
Synonyms:
MLS000054352 | SMR000066061 | [1-(4-chlorophenyl)-3-methyl-5-thieno[2,3-c]pyrazolyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [1-(4-chlorophenyl)-3-methyl-thieno[2,3-c]pyrazol-5-yl]-(4-pyridin-2-ylpiperazin-1-yl)methanone | [1-(4-chlorophenyl)-3-methyl-thieno[2,3-c]pyrazol-5-yl]-[4-(2-pyridyl)piperazino]methanone | [1-(4-chlorophenyl)-3-methylthieno[2,3-c]pyrazol-5-yl]-(4-pyridin-2-ylpiperazin-1-yl)methanone | cid_2997981
Type:
Small organic molecule
Emp. Form.:
C22H20ClN5OS
Mol. Mass.:
437.945
SMILES:
Cc1nn(-c2ccc(Cl)cc2)c2sc(cc12)C(=O)N1CCN(CC1)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: