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Target
Heat shock protein HSP 90-alpha
Ligand
BDBM32180
Substrate
n/a
Meas. Tech.
Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2
IC50
16099.8±n/a nM
Citation
 PubChem, PC Cell-based secondary assay for identifying Hsp90 inhibitors that degrade Hsp90 client protein Her2 PubChem Bioassay (2007)[AID] 
Target
Name:
Heat shock protein HSP 90-alpha
Synonyms:
HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2
Type:
Molecular Chaperone
Mol. Mass.:
84623.45
Organism:
Homo sapiens (Human)
Description:
P07900
Residue:
732
Sequence:
MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD
  
Inhibitor
Name:
BDBM32180
Synonyms:
3-(aminomethyl)-4-fluoranyl-N-(6-oxidanylquinolin-8-yl)benzenesulfonamide | 3-(aminomethyl)-4-fluoro-N-(6-hydroxy-8-quinolinyl)benzenesulfonamide | 3-(aminomethyl)-4-fluoro-N-(6-hydroxy-8-quinolyl)benzenesulfonamide | 3-(aminomethyl)-4-fluoro-N-(6-hydroxyquinolin-8-yl)benzenesulfonamide | TG2-56-1 | cid_16072274
Type:
Small organic molecule
Emp. Form.:
C16H14FN3O3S
Mol. Mass.:
347.364
SMILES:
NCc1cc(ccc1F)S(=O)(=O)Nc1cc(O)cc2cccnc12
Structure:
Search PDB for entries with ligand similarity: