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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM31693
Substrate
n/a
Meas. Tech.
TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70
IC50
>100000±0 nM
Citation
 PubChem, PC TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 PubChem Bioassay (2008)[AID] 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HSPA1A | Heat Shock 70kDa Protein 1 | V9GZ37_HUMAN | heat shock 70kDa protein 1A
Type:
ATP-binding protein
Mol. Mass.:
51937.99
Organism:
Homo sapiens (Human)
Description:
gi_123271505; GST-tagged ATPase domain
Residue:
476
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM31693
Synonyms:
4-[(2,5-Diethoxy-phenylcarbamoyl)-methyl]-piperazine-1-carboxylic acid ethyl ester | 4-[2-(2,5-diethoxyanilino)-2-keto-ethyl]piperazine-1-carboxylic acid ethyl ester;hydrochloride | 4-[2-(2,5-diethoxyanilino)-2-oxoethyl]-1-piperazinecarboxylic acid ethyl ester;hydrochloride | MLS000076321 | SMR000000824 | cid_6603397 | ethyl 4-[2-(2,5-diethoxyanilino)-2-oxoethyl]piperazine-1-carboxylate;hydrochloride | ethyl 4-[2-[(2,5-diethoxyphenyl)amino]-2-oxidanylidene-ethyl]piperazine-1-carboxylate;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C19H29N3O5
Mol. Mass.:
379.4507
SMILES:
CCOC(=O)N1CCN(CC(=O)Nc2cc(OCC)ccc2OCC)CC1
Structure:
Search PDB for entries with ligand similarity: