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Target
Focal adhesion kinase 1
Ligand
BDBM41084
Substrate
n/a
Meas. Tech.
Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK)
IC50
3247±n/a nM
Citation
 PubChem, PC Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) PubChem Bioassay (2007)[AID] 
Target
Name:
Focal adhesion kinase 1
Synonyms:
FADK 1 | FAK | FAK1 | FAK1_HUMAN | FLT4 | FRNK | Focal adhesion kinase (FAK) | Focal adhesion kinase (PTK2) | Focal adhesion kinase 1 (FAK) | Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 | Focal adhesion kinase-related nonkinase | PPP1R71 | PTK2 | Protein phosphatase 1 regulatory subunit 71 | Protein-tyrosine kinase 2 | VHL/Focal adhesion kinase 1 | p125FAK | pp125FAK
Type:
Tyrosine-protein kinase
Mol. Mass.:
119233.17
Organism:
Homo sapiens (Human)
Description:
Q05397
Residue:
1052
Sequence:
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
  
Inhibitor
Name:
BDBM41084
Synonyms:
MLS000571311 | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-keto-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxidanylidene-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxo-2H-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxochromene-3-carboxamide | N-[3-(2-imidazo[1,2-a]pyridinyl)phenyl]-2-oxo-1-benzopyran-3-carboxamide | SMR000193680 | cid_2877674
Type:
Small organic molecule
Emp. Form.:
C23H15N3O3
Mol. Mass.:
381.3835
SMILES:
O=C(Nc1cccc(c1)-c1cn2ccccc2n1)c1cc2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: