Target
Cathepsin B
Ligand
BDBM35497
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
2247.2±181.7 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM35497
Synonyms:
2-[[5,6-bis(2-furanyl)-1,2,4-triazin-3-yl]thio]-N-phenylacetamide | 2-[[5,6-bis(2-furyl)-1,2,4-triazin-3-yl]thio]-N-phenyl-acetamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-phenyl-ethanamide | 2-[[5,6-bis(furan-2-yl)-1,2,4-triazin-3-yl]sulfanyl]-N-phenylacetamide | MLS000036674 | SMR000037724 | cid_5293426
Type:
Small organic molecule
Emp. Form.:
C19H14N4O3S
Mol. Mass.:
378.404
SMILES:
O=C(CSc1nnc(-c2ccco2)c(n1)-c1ccco1)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: