Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM41106
Substrate
n/a
Meas. Tech.
Cathepsin B dose-response confirmation
IC50
>50000±0 nM
Citation
 PubChem, PC Cathepsin B dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM41106
Synonyms:
MLS000058460 | N-(3-cyano-2-thienyl)pyrazinamide | N-(3-cyano-2-thiophenyl)-2-pyrazinecarboxamide | N-(3-cyanothiophen-2-yl)pyrazine-2-carboxamide | SMR000068005 | cid_2612950
Type:
Small organic molecule
Emp. Form.:
C10H6N4OS
Mol. Mass.:
230.246
SMILES:
O=C(Nc1sccc1C#N)c1cnccn1
Structure:
Search PDB for entries with ligand similarity: