Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM41168
Substrate
n/a
Meas. Tech.
Cathepsin L dose-response confirmation
IC50
44815.55±6560.74884 nM
Citation
 PubChem, PC Cathepsin L dose-response confirmation PubChem Bioassay (2008)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM41168
Synonyms:
1-[5-(4-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]carbonyl}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]pyrrolidin-2-one | 1-[5-[4-(4-piperonylpiperazine-1-carbonyl)piperidino]-1,3,4-thiadiazol-2-yl]-2-pyrrolidone | 1-[5-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]carbonylpiperidin-1-yl]-1,3,4-thiadiazol-2-yl]pyrrolidin-2-one | 1-[5-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]piperidin-1-yl]-1,3,4-thiadiazol-2-yl]pyrrolidin-2-one | 1-[5-[4-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-oxomethyl]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-2-pyrrolidinone | MLS000094334 | SMR000029924 | cid_3244559
Type:
Small organic molecule
Emp. Form.:
C24H30N6O4S
Mol. Mass.:
498.598
SMILES:
O=C(C1CCN(CC1)c1nnc(s1)N1CCCC1=O)N1CCN(Cc2ccc3OCOc3c2)CC1
Structure:
Search PDB for entries with ligand similarity: