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Target
Apoptosis regulator Bcl-2
Ligand
BDBM32275
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
24930±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM32275
Synonyms:
(4-Chloro-6-morpholin-4-yl-[1,3,5]triazin-2-yl)-pyridin-3-ylmethyl-amine | (4-chloro-6-morpholino-s-triazin-2-yl)-(3-pyridylmethyl)amine | 4-chloranyl-6-morpholin-4-yl-N-(pyridin-3-ylmethyl)-1,3,5-triazin-2-amine | 4-chloro-6-(4-morpholinyl)-N-(3-pyridinylmethyl)-1,3,5-triazin-2-amine | 4-chloro-6-morpholin-4-yl-N-(pyridin-3-ylmethyl)-1,3,5-triazin-2-amine | MLS000121154 | SMR000118549 | cid_684642
Type:
Small organic molecule
Emp. Form.:
C13H15ClN6O
Mol. Mass.:
306.751
SMILES:
Clc1nc(NCc2cccnc2)nc(n1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: