Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM33127
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
EC50
4380±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 PubChem Bioassay (2008)[AID] 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM33127
Synonyms:
MLS000392290 | N-[3-(3-chloro-4-methyl-anilino)-1,4-diketo-2-naphthyl]benzamide | N-[3-(3-chloro-4-methylanilino)-1,4-dioxo-2-naphthalenyl]benzamide | N-[3-(3-chloro-4-methylanilino)-1,4-dioxonaphthalen-2-yl]benzamide | N-[3-[(3-chloranyl-4-methyl-phenyl)amino]-1,4-bis(oxidanylidene)naphthalen-2-yl]benzamide | SMR000261286 | cid_5082182
Type:
Small organic molecule
Emp. Form.:
C24H17ClN2O3
Mol. Mass.:
416.856
SMILES:
Cc1ccc(NC2=C(NC(=O)c3ccccc3)C(=O)c3ccccc3C2=O)cc1Cl |c:6|
Structure:
Search PDB for entries with ligand similarity: