Reaction Details Report a problem with these data
Target
Cell division control protein 42 homolog
Ligand
BDBM43215
Substrate
n/a
Meas. Tech.
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
EC50
20590±n/a nM
Citation
 PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay (2010)[AID] 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM43215
Synonyms:
5-[[(3-chlorobenzyl)thio]methyl]-N-piperonyl-2-furamide | MLS000584564 | N-(1,3-benzodioxol-5-ylmethyl)-5-[(3-chlorophenyl)methylsulfanylmethyl]furan-2-carboxamide | N-(1,3-benzodioxol-5-ylmethyl)-5-[[(3-chlorophenyl)methylthio]methyl]-2-furancarboxamide | N-(1,3-benzodioxol-5-ylmethyl)-5-{[(3-chlorobenzyl)thio]methyl}-2-furamide | SMR000207149 | cid_5085445
Type:
Small organic molecule
Emp. Form.:
C21H18ClNO4S
Mol. Mass.:
415.89
SMILES:
Clc1cccc(CSCc2ccc(o2)C(=O)NCc2ccc3OCOc3c2)c1
Structure:
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