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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43372
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
7390±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43372
Synonyms:
4-(2,6-Dimethyl-morpholin-4-yl)-8-methoxy-5H-pyrimido[5,4-b]indole | 4-(8-methoxy-5H-pyrimid[5,4-b]indol-4-yl)-2,6-dimethyl-morpholine | 4-(8-methoxy-5H-pyrimido[5,4-b]indol-4-yl)-2,6-dimethyl-morpholine | 4-(8-methoxy-5H-pyrimido[5,4-b]indol-4-yl)-2,6-dimethylmorpholine | MLS000556377 | SMR000147694 | cid_3832575
Type:
Small organic molecule
Emp. Form.:
C17H20N4O2
Mol. Mass.:
312.3663
SMILES:
COc1ccc2[nH]c3c(ncnc3c2c1)N1CC(C)OC(C)C1
Structure:
Search PDB for entries with ligand similarity: