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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43432
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
7190±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43432
Synonyms:
4-[(4-fluorobenzyl)thio]-2-methyl-5-nitro-1H-imidazole | 4-[(4-fluorophenyl)methylsulfanyl]-2-methyl-5-nitro-1H-imidazole | 4-[(4-fluorophenyl)methylthio]-2-methyl-5-nitro-1H-imidazole | 5-[(4-fluorobenzyl)thio]-2-methyl-4-nitro-1H-imidazole | MLS000677201 | SMR000271028 | cid_801720
Type:
Small organic molecule
Emp. Form.:
C11H10FN3O2S
Mol. Mass.:
267.279
SMILES:
Cc1nc(c(SCc2ccc(F)cc2)[nH]1)[N+]([O-])=O
Structure:
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