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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43439
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
84990±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43439
Synonyms:
3-[(2,5-dimethoxybenzyl)amino]-2-(2-fluorophenyl)quinazolin-4(3H)-one | 3-[(2,5-dimethoxybenzyl)amino]-2-(2-fluorophenyl)quinazolin-4-one | 3-[(2,5-dimethoxyphenyl)methylamino]-2-(2-fluorophenyl)-4-quinazolinone | 3-[(2,5-dimethoxyphenyl)methylamino]-2-(2-fluorophenyl)quinazolin-4-one | MLS000723897 | SMR000305492 | cid_16187970
Type:
Small organic molecule
Emp. Form.:
C23H20FN3O3
Mol. Mass.:
405.4216
SMILES:
COc1ccc(OC)c(CNn2c(nc3ccccc3c2=O)-c2ccccc2F)c1
Structure:
Search PDB for entries with ligand similarity: