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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43462
Substrate
n/a
Meas. Tech.
E3 Ligase dose-response_384
EC50
3980±n/a nM
Citation
 PubChem, PC E3 Ligase dose-response_384 PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43462
Synonyms:
2-[[(1-methyl-4-quinolinylidene)amino]methylidene]propanedinitrile | 2-[[(1-methyl-4-quinolylidene)amino]methylene]malononitrile | 2-[[(1-methylquinolin-4-ylidene)amino]methylidene]propanedinitrile | MLS000710817 | SMR000280584 | cid_789838
Type:
Small organic molecule
Emp. Form.:
C14H10N4
Mol. Mass.:
234.256
SMILES:
Cn1cc\c(=N/C=C(C#N)C#N)c2ccccc12 |(7.08,5,;7.08,3.47,;5.75,2.7,;5.75,1.16,;7.08,.39,;7.08,-1.16,;5.75,-1.93,;5.75,-3.47,;4.41,-4.24,;3.08,-5,;7.08,-4.24,;8.41,-5,;8.41,1.16,;9.79,.33,;11.19,1.12,;11.19,2.73,;9.79,3.52,;8.41,2.7,)|
Structure:
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