Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44369
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells.
IC50
>10000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44369
Synonyms:
2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine | 2-(4-chlorophenyl)-4-(ethylthio)-6-pyrrolidino-pyrimidine | 2-(4-chlorophenyl)-4-ethylsulfanyl-6-pyrrolidin-1-yl-pyrimidine | 2-(4-chlorophenyl)-4-ethylsulfanyl-6-pyrrolidin-1-ylpyrimidine | MLS-0390923.0001 | cid_852319
Type:
Small organic molecule
Emp. Form.:
C16H18ClN3S
Mol. Mass.:
319.852
SMILES:
CCSc1cc(nc(n1)-c1ccc(Cl)cc1)N1CCCC1
Structure:
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