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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44405
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
3670±130 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44405
Synonyms:
6,6-dimethyl-3-(2-thienyl)-5,7-dihydro-1H-indazol-4-one | 6,6-dimethyl-3-thien-2-yl-1,5,6,7-tetrahydro-4H-indazol-4-one | 6,6-dimethyl-3-thiophen-2-yl-5,7-dihydro-1H-indazol-4-one | MLS000085242 | SMR000019980 | cid_712788
Type:
Small organic molecule
Emp. Form.:
C13H14N2OS
Mol. Mass.:
246.328
SMILES:
CC1(C)Cc2[nH]nc(-c3cccs3)c2C(=O)C1
Structure:
Search PDB for entries with ligand similarity: