Reaction Details Report a problem with these data
Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM46308
Substrate
n/a
Meas. Tech.
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein.
EC50
12800±n/a nM
Citation
 PubChem, PC Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B protein. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM46308
Synonyms:
2-[(1,1-dioxo-1,2-benzothiazol-3-yl)-[(phenylmethylene)amino]amino]ethanol | 2-[(benzalamino)-(1,1-diketo-1,2-benzothiazol-3-yl)amino]ethanol | 2-[(benzylideneamino)-(1,1-dioxo-1,2-benzothiazol-3-yl)amino]ethanol | 2-[[1,1-bis(oxidanylidene)-1,2-benzothiazol-3-yl]-[(phenylmethylidene)amino]amino]ethanol | MLS000682941 | SMR000313024 | benzaldehyde (1,1-dioxido-1,2-benzisothiazol-3-yl)(2-hydroxyethyl)hydrazone | cid_3550050
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3S
Mol. Mass.:
329.374
SMILES:
OCCN(N=Cc1ccccc1)C1=NS(=O)(=O)c2ccccc12 |w:4.3,t:13|
Structure:
Search PDB for entries with ligand similarity: