Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46339
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
4220±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46339
Synonyms:
4-Amino-3-cyclohexylcarbamoyl-isothiazole-5-carboxylic acid cyclohexylcarbamoylmethyl ester | 4-amino-3-(cyclohexylcarbamoyl)isothiazole-5-carboxylic acid [2-(cyclohexylamino)-2-keto-ethyl] ester | 4-amino-3-[(cyclohexylamino)-oxomethyl]-5-isothiazolecarboxylic acid [2-(cyclohexylamino)-2-oxoethyl] ester | MLS000031169 | SMR000006300 | [2-(cyclohexylamino)-2-oxidanylidene-ethyl] 4-azanyl-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate | [2-(cyclohexylamino)-2-oxoethyl] 4-amino-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate | cid_651494
Type:
Small organic molecule
Emp. Form.:
C19H28N4O4S
Mol. Mass.:
408.515
SMILES:
Nc1c(nsc1C(=O)OCC(=O)NC1CCCCC1)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: