Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46391
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
4442±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46391
Synonyms:
2-chlorobenzoic acid [3-(4-quinazolinylamino)phenyl] ester | 2-chlorobenzoic acid [3-(quinazolin-4-ylamino)phenyl] ester | 3-(4-quinazolinylamino)phenyl 2-chlorobenzoate | MLS000575694 | SMR000196728 | [3-(quinazolin-4-ylamino)phenyl] 2-chloranylbenzoate | [3-(quinazolin-4-ylamino)phenyl] 2-chlorobenzoate | cid_1187613
Type:
Small organic molecule
Emp. Form.:
C21H14ClN3O2
Mol. Mass.:
375.808
SMILES:
Clc1ccccc1C(=O)Oc1cccc(Nc2ncnc3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: