Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43528
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
22020±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43528
Synonyms:
(4-chlorophenyl)-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]methanone | (4-chlorophenyl)-[4-(7-chloro-4-quinolyl)piperazino]methanone | (4-chlorophenyl)-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]methanone | 7-chloro-4-[4-(4-chlorobenzoyl)-1-piperazinyl]quinoline | MLS000676065 | SMR000296226 | [4-(7-chloranylquinolin-4-yl)piperazin-1-yl]-(4-chlorophenyl)methanone | cid_1251584
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2N3O
Mol. Mass.:
386.274
SMILES:
Clc1ccc(cc1)C(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
Structure:
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