Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43533
Substrate
n/a
Meas. Tech.
Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen for STAT1 inhibitors: cell-based high throughput assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43533
Synonyms:
3-(3,4-dimethoxyphenyl)-2-(3-pyridinylmethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4-one | 3-(3,4-dimethoxyphenyl)-2-(3-pyridylmethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4-one | 3-(3,4-dimethoxyphenyl)-2-(pyridin-3-ylmethylsulfanyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4-one | MLS000685296 | SMR000324052 | cid_16194761
Type:
Small organic molecule
Emp. Form.:
C20H19N3O3S2
Mol. Mass.:
413.513
SMILES:
COc1ccc(cc1OC)-n1c(SCc2cccnc2)nc2CCSc2c1=O
Structure:
Search PDB for entries with ligand similarity: