Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46920
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
2760±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46920
Synonyms:
MLS000548236 | N-[2,6-dimethyl-3-[4-(2-methylallyl)piperazino]sulfonyl-phenyl]-N,4-dimethyl-benzenesulfonamide | N-[2,6-dimethyl-3-[4-(2-methylprop-2-enyl)piperazin-1-yl]sulfonyl-phenyl]-N,4-dimethyl-benzenesulfonamide | N-[2,6-dimethyl-3-[4-(2-methylprop-2-enyl)piperazin-1-yl]sulfonylphenyl]-N,4-dimethylbenzenesulfonamide | N-[2,6-dimethyl-3-[[4-(2-methylprop-2-enyl)-1-piperazinyl]sulfonyl]phenyl]-N,4-dimethylbenzenesulfonamide | N-{2,6-Dimethyl-3-[4-(2-methyl-allyl)-piperazine-1-sulfonyl]-phenyl}-4,N-dimethyl-benzenesulfonamide | SMR000172295 | cid_2937394
Type:
Small organic molecule
Emp. Form.:
C24H33N3O4S2
Mol. Mass.:
491.667
SMILES:
CN(c1c(C)ccc(c1C)S(=O)(=O)N1CCN(CC(C)=C)CC1)S(=O)(=O)c1ccc(C)cc1
Structure:
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