Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46982
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
17300±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46982
Synonyms:
MLS000830750 | N-[3-(5-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-2H-1,2,3,4-tetraazol-2-yl)phenyl]acetamide | N-[3-[5-[2-(4-methoxyphenyl)-2-oxidanylidene-ethyl]sulfanyl-1,2,3,4-tetrazol-2-yl]phenyl]ethanamide | N-[3-[5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyltetrazol-2-yl]phenyl]acetamide | N-[3-[5-[[2-(4-methoxyphenyl)-2-oxoethyl]thio]-2-tetrazolyl]phenyl]acetamide | N-[3-[5-[[2-keto-2-(4-methoxyphenyl)ethyl]thio]tetrazol-2-yl]phenyl]acetamide | SMR000458171 | cid_2810542
Type:
Small organic molecule
Emp. Form.:
C18H17N5O3S
Mol. Mass.:
383.424
SMILES:
COc1ccc(cc1)C(=O)CSc1nnn(n1)-c1cccc(NC(C)=O)c1
Structure:
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