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Target
Mucolipin-3
Ligand
BDBM46986
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
2490±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46986
Synonyms:
4-chloro-2-[(2-chloro-6-fluoro-benzyl)-mesyl-amino]benzoic acid methyl ester | 4-chloro-2-[(2-chloro-6-fluorophenyl)methyl-methylsulfonylamino]benzoic acid methyl ester | MLS000849772 | SMR000455790 | cid_2799891 | methyl 4-chloranyl-2-[(2-chloranyl-6-fluoranyl-phenyl)methyl-methylsulfonyl-amino]benzoate | methyl 4-chloro-2-[(2-chloro-6-fluorobenzyl)(methylsulfonyl)amino]benzoate | methyl 4-chloro-2-[(2-chloro-6-fluorophenyl)methyl-methylsulfonylamino]benzoate
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2FNO4S
Mol. Mass.:
406.256
SMILES:
COC(=O)c1ccc(Cl)cc1N(Cc1c(F)cccc1Cl)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: