Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 8
Ligand
BDBM47711
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47711
Synonyms:
5-methyl-2-[[oxo(3-pyridinyl)methyl]amino]-3-thiophenecarboxylic acid methyl ester | 5-methyl-2-nicotinamido-thiophene-3-carboxylic acid methyl ester | MLS000065647 | SMR000080289 | cid_1245092 | methyl 5-methyl-2-(pyridin-3-ylcarbonylamino)thiophene-3-carboxylate | methyl 5-methyl-2-(pyridine-3-carbonylamino)thiophene-3-carboxylate | methyl 5-methyl-2-[(3-pyridinylcarbonyl)amino]-3-thiophenecarboxylate
Type:
Small organic molecule
Emp. Form.:
C13H12N2O3S
Mol. Mass.:
276.311
SMILES:
COC(=O)c1cc(C)sc1NC(=O)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: