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Target
Regulator of G-protein signaling 8
Ligand
BDBM47721
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47721
Synonyms:
MLS000523066 | N-[2-[6-[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonyl-3-oxidanylidene-4H-quinoxalin-2-yl]phenyl]ethanamide | N-[2-[6-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3-keto-4H-quinoxalin-2-yl]phenyl]acetamide | N-[2-[6-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3-oxo-4H-quinoxalin-2-yl]phenyl]acetamide | N-[2-[6-[[4-(2,5-dimethylphenyl)-1-piperazinyl]-oxomethyl]-3-oxo-4H-quinoxalin-2-yl]phenyl]acetamide | SMR000128332 | cid_9551426
Type:
Small organic molecule
Emp. Form.:
C29H29N5O3
Mol. Mass.:
495.5723
SMILES:
CC(=O)Nc1ccccc1-c1nc2ccc(cc2[nH]c1=O)C(=O)N1CCN(CC1)c1cc(C)ccc1C
Structure:
Search PDB for entries with ligand similarity: