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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48057
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
10000±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48057
Synonyms:
3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-p-anisyl-thieno[2,3-b]pyridine-2-carboxamide | 3-amino-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methyl-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methylthieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-6-[3-(dimethylamino)propoxy]-N-[(4-methoxyphenyl)methyl]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | VU0152117 | cid_45142469
Type:
Small organic molecule
Emp. Form.:
C22H28N4O3S
Mol. Mass.:
428.548
SMILES:
COc1ccc(CNC(=O)c2sc3nc(OCCCN(C)C)cc(C)c3c2N)cc1
Structure:
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