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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48077
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
1580±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48077
Synonyms:
3-amino-N-(2,5-difluorobenzyl)-4-methyl-6-(4-pyridylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-4-methyl-6-(pyridin-4-ylmethoxy)-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-4-methyl-6-(pyridin-4-ylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-[[2,5-bis(fluoranyl)phenyl]methyl]-4-methyl-6-(pyridin-4-ylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | VU0359509 | cid_45142487
Type:
Small organic molecule
Emp. Form.:
C22H18F2N4O2S
Mol. Mass.:
440.466
SMILES:
Cc1cc(OCc2ccncc2)nc2sc(C(=O)NCc3cc(F)ccc3F)c(N)c12
Structure:
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