Reaction Details Report a problem with these data
Target
D(1B) dopamine receptor
Ligand
BDBM48941
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen
EC50
2.36e-05±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen PubChem Bioassay (2007)[AID] 
Target
Name:
D(1B) dopamine receptor
Synonyms:
D(5) dopamine receptor | D1beta dopamine receptor | DOPAMINE D5 | DRD1B | DRD1L2 | DRD5 | DRD5_HUMAN | dopamine receptor D5
Type:
Protein
Mol. Mass.:
52943.41
Organism:
Homo sapiens (Human)
Description:
P21918
Residue:
477
Sequence:
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
  
Inhibitor
Name:
BDBM48941
Synonyms:
4-hydroxy-6-(4-isopropylphenyl)-2-piperidin-1-ylpyrimidine-5-carbonitrile | 4-keto-6-p-cumenyl-2-piperidino-1H-pyrimidine-5-carbonitrile | 4-oxidanylidene-2-piperidin-1-yl-6-(4-propan-2-ylphenyl)-1H-pyrimidine-5-carbonitrile | 4-oxo-2-(1-piperidinyl)-6-(4-propan-2-ylphenyl)-1H-pyrimidine-5-carbonitrile | 4-oxo-2-piperidin-1-yl-6-(4-propan-2-ylphenyl)-1H-pyrimidine-5-carbonitrile | MLS000044630 | SMR000022574 | cid_891760
Type:
Small organic molecule
Emp. Form.:
C19H22N4O
Mol. Mass.:
322.4042
SMILES:
CC(C)c1ccc(cc1)-c1nc([nH]c(=O)c1C#N)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: