Reaction Details Report a problem with these data
Target
D(1B) dopamine receptor
Ligand
BDBM48948
Substrate
n/a
Meas. Tech.
Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen
EC50
0.00361±n/a nM
Citation
 PubChem, PC Allosteric Modulators of D1 Receptors: Dose-dependent Counterscreen PubChem Bioassay (2007)[AID] 
Target
Name:
D(1B) dopamine receptor
Synonyms:
D(5) dopamine receptor | D1beta dopamine receptor | DOPAMINE D5 | DRD1B | DRD1L2 | DRD5 | DRD5_HUMAN | dopamine receptor D5
Type:
Protein
Mol. Mass.:
52943.41
Organism:
Homo sapiens (Human)
Description:
P21918
Residue:
477
Sequence:
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
  
Inhibitor
Name:
BDBM48948
Synonyms:
MLS000044676 | N-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-2-ethyl-6,7-dimethoxy-1-oxo-1,2-dihydroisoquinoline-4-carboxamide | N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-ethyl-1-keto-6,7-dimethoxy-isoquinoline-4-carboxamide | N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-ethyl-6,7-dimethoxy-1-oxidanylidene-isoquinoline-4-carboxamide | N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-ethyl-6,7-dimethoxy-1-oxo-4-isoquinolinecarboxamide | N-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-2-ethyl-6,7-dimethoxy-1-oxoisoquinoline-4-carboxamide | SMR000022620 | cid_3244930
Type:
Small organic molecule
Emp. Form.:
C23H24N2O6
Mol. Mass.:
424.4465
SMILES:
CCn1cc(C(=O)NCC2COc3ccccc3O2)c2cc(OC)c(OC)cc2c1=O
Structure:
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