Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43366
Substrate
n/a
Meas. Tech.
E3 Ligase_Mutant_Dose Response
EC50
1420±n/a nM
Citation
 PubChem, PC E3 Ligase_Mutant_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43366
Synonyms:
5'-isopropyl-5-phenyl-spiro[3H-1,3,4-thiadiazole-2,3'-indoline]-2'-one | 5'-phenyl-5-propan-2-yl-2-spiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]one | 5'-phenyl-5-propan-2-yl-spiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one | 5'-phenyl-5-propan-2-ylspiro[1H-indole-3,2'-3H-1,3,4-thiadiazole]-2-one | MLS000528096 | SMR000120670 | cid_3154392
Type:
Small organic molecule
Emp. Form.:
C18H17N3OS
Mol. Mass.:
323.412
SMILES:
CC(C)c1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1 |c:12|
Structure:
Search PDB for entries with ligand similarity: