Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 4
Ligand
BDBM47795
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao.
EC50
30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 4
Synonyms:
RGP4 | RGS4 | RGS4_HUMAN | Regulator of G-protein signaling 4 (RGS4)
Type:
Enzyme
Mol. Mass.:
23263.51
Organism:
Homo sapiens (Human)
Description:
P49798
Residue:
205
Sequence:
MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA
  
Inhibitor
Name:
BDBM47795
Synonyms:
MLS000686223 | N-[2-(2-methoxyphenyl)ethyl]-2-[(6-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]acetamide | N-[2-(2-methoxyphenyl)ethyl]-2-[(6-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]ethanamide | N-[2-(2-methoxyphenyl)ethyl]-2-[[6-(3-pyridinyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]thio]acetamide | N-[2-(2-methoxyphenyl)ethyl]-2-[[6-(3-pyridyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]thio]acetamide | SMR000324246 | cid_16194780
Type:
Small organic molecule
Emp. Form.:
C21H20N6O2S
Mol. Mass.:
420.487
SMILES:
COc1ccccc1CCNC(=O)CSc1nnc2ccc(nn12)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: