Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 6
Ligand
BDBM51780
Substrate
n/a
Meas. Tech.
MKP-3 in vitro HTS assay
IC50
12000±n/a nM
Citation
 PubChem, PC MKP-3 in vitro HTS assay PubChem Bioassay (2009)[AID] 
Target
Name:
Dual specificity protein phosphatase 6
Synonyms:
DUS6_RAT | Dusp6 | MAP kinase phosphatase 3 | MKP-3 | Mitogen-activated protein kinase phosphatase 3 | Mkp3
Type:
Enzyme
Mol. Mass.:
42303.19
Organism:
Rattus norvegicus
Description:
gi_16758752
Residue:
381
Sequence:
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
  
Inhibitor
Name:
BDBM51780
Synonyms:
5-[5-(6-Bromo-3-oxo-benzo[4,5]imidazo[2,1-b]thiazol-2-ylidenemethyl)-furan-2-yl]-2-chloro-benzoic acid | 5-[5-[(7-bromanyl-1-oxidanylidene-[1,3]thiazolo[3,2-a]benzimidazol-2-ylidene)methyl]furan-2-yl]-2-chloranyl-benzoic acid | 5-[5-[(7-bromo-1-keto-thiazolo[3,2-a]benzimidazol-2-ylidene)methyl]-2-furyl]-2-chloro-benzoic acid | 5-[5-[(7-bromo-1-oxo-2-thiazolo[3,2-a]benzimidazolylidene)methyl]-2-furanyl]-2-chlorobenzoic acid | 5-[5-[(7-bromo-1-oxo-[1,3]thiazolo[3,2-a]benzimidazol-2-ylidene)methyl]furan-2-yl]-2-chlorobenzoic acid | MLS001207823 | SMR000516642 | cid_3129904
Type:
Small organic molecule
Emp. Form.:
C21H10BrClN2O4S
Mol. Mass.:
501.737
SMILES:
OC(=O)c1cc(ccc1Cl)-c1ccc(C=c2sc3nc4ccc(Br)cc4n3c2=O)o1
Structure:
Search PDB for entries with ligand similarity: