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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM53545
Substrate
n/a
Meas. Tech.
HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target
IC50
100000±n/a nM
Citation
 PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay (2008)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM53545
Synonyms:
2-[4-(2-fluorophenyl)-1-piperazinyl]-N-(4-methoxyphenyl)acetamide | 2-[4-(2-fluorophenyl)piperazin-1-yl]-N-(4-methoxyphenyl)acetamide | 2-[4-(2-fluorophenyl)piperazin-1-yl]-N-(4-methoxyphenyl)ethanamide | 2-[4-(2-fluorophenyl)piperazino]-N-(4-methoxyphenyl)acetamide | MLS000047416 | SMR000033427 | cid_759055
Type:
Small organic molecule
Emp. Form.:
C19H22FN3O2
Mol. Mass.:
343.3953
SMILES:
COc1ccc(NC(=O)CN2CCN(CC2)c2ccccc2F)cc1
Structure:
Search PDB for entries with ligand similarity: