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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34628
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34628
Synonyms:
4-bromanyl-2-(4-methoxyphenyl)-6-methyl-benzotriazol-5-amine | 4-bromo-2-(4-methoxyphenyl)-6-methyl-2H-1,2,3-benzotriazol-5-amine | 4-bromo-2-(4-methoxyphenyl)-6-methyl-5-benzotriazolamine | 4-bromo-2-(4-methoxyphenyl)-6-methylbenzotriazol-5-amine | MLS000052623 | SMR000082196 | [4-bromo-2-(4-methoxyphenyl)-6-methyl-benzotriazol-5-yl]amine | cid_2236497
Type:
Small organic molecule
Emp. Form.:
C14H13BrN4O
Mol. Mass.:
333.183
SMILES:
COc1ccc(cc1)-n1nc2cc(C)c(N)c(Br)c2n1
Structure:
Search PDB for entries with ligand similarity: