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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34644
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
23273±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34644
Synonyms:
(6E)-6-[(2,4-dimethylanilino)methylene]-2-hydroxy-cyclohexa-2,4-dien-1-one | (6E)-6-[(2,4-dimethylanilino)methylidene]-2-hydroxy-1-cyclohexa-2,4-dienone | (6E)-6-[(2,4-dimethylanilino)methylidene]-2-hydroxycyclohexa-2,4-dien-1-one | (6E)-6-[[(2,4-dimethylphenyl)amino]methylidene]-2-oxidanyl-cyclohexa-2,4-dien-1-one | MLS000105370 | SMR000102251 | cid_5720124
Type:
Small organic molecule
Emp. Form.:
C15H15NO2
Mol. Mass.:
241.2851
SMILES:
Cc1ccc(N=Cc2cccc(O)c2O)c(C)c1 |w:5.4|
Structure:
Search PDB for entries with ligand similarity: